“I remember falling that day. Hi, first sign of MS!” she said to the show’s creator Liz Feldman on Applegate and Jamie-Lynn Sigler’s MeSsy podcast, recalling a sequence in which her character Jen was running across a field.

Christina Applegate's multiple sclerosis battle began long before she was diagnosed with the disease in 2021. On the latest episode of her "MeSsy" podcast with Jamie-Lynn Sigler, Applegate recalled experiencing her first symptoms of MS during the pilot for the Netflix show Dead to Me in 2019,

Speaking on the latest episode of her MeSsy podcast, which she co-hosts with Jamie-Lynn Sigler, who also has MS, Applegate explained how she fell over while filming a running sequence in a field. She didn’t realize it at the time, but this was an early sign of her MS.