Minimum and Maximum Doses of Trazodone for Sleep When using trazodone for sleep, the drug is given at low doses—typically ...

The recommended trazodone dosage for major depressive disorder (MDD) is between 150 milligrams (mg) and 400 mg ... Trazodone is only approved by the Food and Drug Administration (FDA) for MDD.

[1] Trazodone is an old second-generation antidepressant with strong sedative activity, widely used as a hypnotic drug in subtherapeutic antidepressant doses of 100 mg or less, although the ...