Matt Maiocco reveals which five 49ers players must step up in San Francisco's must-win Week 13 game against the Buffalo Bills ...

Running back Christian McCaffrey says the 49ers are “hungry” to make a playoff push even with the defending NFC champions ...

San Francisco 49ers first-year defensive coordinator Nick Sorensen isn't focused on the outside scrutiny he's facing amid the ...

Missed the last seven snaps of the loss to Packers and was placed on concussion protocol upon the 49ers’ return home, Banks ...

San Francisco 49ers star quarterback Brock Purdy has been given an injury update in time for their Week 13 match up against ...

The San Francisco 49ers have released their final injury report ahead of their Week 13 bout with the Buffalo Bills.

Heavy, lake-effect snow will fall on Buffalo this weekend as the 49ers arrive to face the Bills on Sunday night in the suburb ...

San Francisco 49ers quarterback Brock Purdy is expected to return to the field on Sunday against the Buffalo Bills after ...

Purdy missed the 49ers' Week 12 contest versus the Green Bay Packers last Sunday with a right shoulder injury—a game San ...

Defensively, two of the 49ers’ best players this season are out and will not travel as defensive end Nick Bosa (obliques, ...

Brock Purdy is expected to return Sunday night against the Bills, but offensive tackle Trent Williams, defensive end Nick ...