Taking the field in Week 1 with sky-high expectations, what with eight-year head coach Kyle Shanahan having just taken his ...

The San Francisco 49ers have released their final injury report ahead of their Week 13 bout with the Buffalo Bills.

The San Francisco 49ers are up against the Buffalo Bills in Week 13. The 49ers have dealt with an array of injuries this ...

Purdy missed the 49ers' Week 12 contest versus the Green Bay Packers last Sunday with a right shoulder injury—a game San ...

San Francisco 49ers star quarterback Brock Purdy has been given an injury update in time for their Week 13 match up against ...

The San Francisco 49ers announced Friday that they have waived wide receiver Ronnie Bell ahead of their Sunday night game ...

Running back Christian McCaffrey refuses to buy into the doom and gloom surrounding the San Francisco 49ers since two ...

The NFL is just about as unpredictable as the Buffalo weather at this time of the year, so the 49ers will take their ...

The Buffalo Bills have the chance to make team history on "Sunday Night Football" against the San Francisco 49ers.

San Francisco 49ers quarterback Brock Purdy is expected to return to the field on Sunday against the Buffalo Bills after ...

San Francisco 49ers quarterback Brock Purdy is expected to return Sunday against the Buffalo Bills, head coach Kyle Shanahan ...

Brock Purdy is expected to return Sunday night against the Bills, but offensive tackle Trent Williams, defensive end Nick ...