The San Francisco 49ers may be down to their fourth-string running back Thursday against the Los Angeles Rams. Head coach ...

With running backs Christian McCaffrey and Jordan Mason on IR, the 49ers turned to rookie RB Isaac Guerendo to start their ...

The San Francisco 49ers sustained another injury at running back during their Sunday contest against the Chicago Bears.

Now, it looks as though the 49ers may be down yet another running back, as Isaac Guerendo was forced out of Sunday’s game ...

The 49ers are playing on "Thursday Night Football" against the Rams. Will running back Isaac Guerendo be ready to play after ...

The Bears take on the 49ers, who are trying to keep their season alive in NFL Week 14. Check out our predictions and best ...

The 49ers have lost both of their top running backs to injuries. So how who will replace Christian McCaffrey and Jordan Mason ...

The 49ers backfield is further and further depleted. Running back Isaac Guerendo is the latest to suffer an injury. We break ...

Isaac Guerendo was elevated from third-string running back to the 49ers starter in Week 14s, filling in for Christian ...

Should Guerendo start as expected Sunday, it will be just his second start as a running back since he was in the fourth grade ...

The Bears elevated running back Darrynton Evans and safety Adrian Colbert from the practice squad for their game against the ...

With Christian McCaffrey and Jordan Mason out with injuries for the San Francisco 49ers, Isaac Guerendo will step into a ...