The San Francisco 49ers may be down to their fourth-string running back Thursday against the Los Angeles Rams. Head coach ...

With running backs Christian McCaffrey and Jordan Mason on IR, the 49ers turned to rookie RB Isaac Guerendo to start their ...

Now, it looks as though the 49ers may be down yet another running back, as Isaac Guerendo was forced out of Sunday’s game ...

The San Francisco 49ers sustained another injury at running back during their Sunday contest against the Chicago Bears.

The 49ers are playing on "Thursday Night Football" against the Rams. Will running back Isaac Guerendo be ready to play after ...

The 49ers have lost both of their top running backs to injuries. So how who will replace Christian McCaffrey and Jordan Mason ...

Isaac Guerendo was elevated from third-string running back to the 49ers starter in Week 14s, filling in for Christian ...

Should Guerendo start as expected Sunday, it will be just his second start as a running back since he was in the fourth grade ...

The Bears elevated running back Darrynton Evans and safety Adrian Colbert from the practice squad for their game against the ...

With Christian McCaffrey and Jordan Mason out with injuries for the San Francisco 49ers, Isaac Guerendo will step into a ...

Christian McCaffrey is dealing with an injury again. The 49ers running back went down with a knee injury in the second ...

Christian McCaffrey and Jordan Mason both landed on IR after the 49ers lost to the Bills in Week 13. Isaac Guerendo will now ...