Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

Guerendo will be the 49ers' lead back after Christian McCaffrey was placed on injured reserve, with Jordan Mason set to ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

McCaffrey posted a statement on Instagram on Wednesday.

McCaffrey was initially said to be out at least six weeks — with five weeks left in the season. Niners head coach Kyle ...

Since returning from an Achilles tendinitis issue, Christian McCaffrey has dominated the San Francisco 49ers' backfield, ...

After being placed on injured reserve following a PCL injury suffered in last Sunday's defeat to the Buffalo Bills, McCaffrey ...