Since training camp, the 49ers season hasn't gone as planned amid injuries to star players and on-field struggles.

On Thursday night, the San Francisco 49ers will host the Los Angeles Rams at Levi's Stadium in what is a must-win game for them and their playoff hopes.

While the 49ers will be without left tackle Trent Williams for a fourth straight game on Thursday night, there's at least a ...

San Francisco 49ers running back Christian McCaffrey was the near-consensus No. 1 pick in fantasy football drafts. However, ...

Charbonnet was amazing in Week 14 against the Arizona Cardinals, going for a career-high 134 rushing yards and two touchdowns ...

San Francisco 49ers running back Christian McCaffrey (knee) suffered a PCL injury just four games into his return from the ...

How high did the Dolphins and 49ers rise and how far did the Bears fall in our Week 15 Power Rankings? Plus, we look at the ...

McCaffrey's old backfield mate discussed the trials and tribulations of a season-ending injury on his podcast.

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

NFL Week 15 odds, picks, predictions, TV channel, streaming for Thursday Night Football game between Los Angeles Rams and San Francisco 49ers.

San Francisco 49ers cornerback Deommodore Lenoir is set to return for Sunday's game against the Chicago Bears after missing ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve and is likely out for the season after suffering a PCL injury in Week 13 agai ...