The EMBO Journal4h
A split intein and split luciferase-coupled system for detecting protein-protein interactions
The split intein-mediated protein ligation (SIMPL) system for detecting protein-protein interactions has been enhanced by ...
The EMBO Journal8h
Cholesterol restriction primes antiviral innate immunity via SREBP1-driven noncanonical type I IFNs
Cholesterol restriction-mediated SREBP1 activation induces noncanonical type I IFNs, including IFN-ω and minor IFN-α subsets, ...
The EMBO Journal1d
The TRIM37 variant rs57141087 contributes to triple-negative breast cancer outcomes in Black women
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The risk variant rs57141087 is predominant in ...
The EMBO Journal7d
Histone methyltransferases MLL2 and SETD1A/B play distinct roles in H3K4me3 deposition during the transition from totipotency to pluripotency
In early mammalian embryogenesis, a shift from non-canonical histone H3 lysine 4 trimethylation (H3K4me3) linked to transcriptional repression to canonical H3K4me3 indicating active promoters occurs ...
The EMBO Journal8d
Rarγ-Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Retinoic acid (RA) signaling is a master ...
The EMBO Journal8d
How J-chain ensures the assembly of immunoglobulin IgM pentamers
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Polymeric IgM immunoglobulins have high ...
The EMBO Journal8d
Mitochondrial calcium uniporter complex controls T-cell-mediated immune responses
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. MCU plays a key role in controlling ...
The EMBO Journal9d
Targeting to BMP9 to restrain flare-up of fibrodysplasia ossificans progressiva
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized primarily by the formation of heterotopic ...
The EMBO Journal9d
Tubulin glutamylation regulates axon guidance via the selective tuning of microtubule-severing enzymes
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The microtubule cytoskeleton is a major ...